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KMID : 0380020030180020161
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Korean Journal of Biotechnology and Bioengineering
2003 Volume.18 No. 2 p.161 ~ p.164
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Release Properties of BSA from Pectin Beads for Colonic Drug Delivery
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Choi Chun-Soon
Park Sang-Moo
Song Won-Hyun
Lee Chang-Moon
Lee Ki-Young
Kim Dong-Won
Kim Jin-Cheol
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Abstract
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Oral drug delivery system using pectin gel was developed for colon-targeting of peptide drug. BSA(bovine serum albumin)-loaded pectin and pectin-alginate beads were prepared for drug release properties in vitro. Morphological studies by electron microscopy indicated that pectin and pectin-alginate beads were spherical in shape and approximately 1.0 mm. In order to find the suitable beads, effects of cross-linking agents (calcium chloride or zinc acetate) and drying temperature of beads were investigated. Drug release decreased with concentration of cross-linking agents and drying temperature. For colonic drug delivery from pectin and pectin-alginate beads, pectin degradable enzymes were added at 5 hrs from the beginning of drug release. After addition of enzymes, drug release was suddenly increased against free enzymes. Therefore, pectin and pectin-alginate beads can be promised as useful drug release carriers for colon-targeted delivery.
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KEYWORD
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Pectin, BSA, colon-target, bead
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